“most human genomes are sequenced from DNA extracted from multiple cells, which misses the differences between cells that could be crucial to controlling gene expression, cell behavior and drug response.” Nicolas Navin is now sequencing from a single cell with minimal errors! Molecular Biology has come a long way over the past decade!
Nicolas Navin wanted to work out the sequence from individual cancer cells to see how they had mutated and diverged as the cancer grew. Back in 2010, he was a postdoctoral fellow at Cold Spring Harbor Laboratory in New York and exploring the genetic changes that occur during breast cancer.
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